Virginia Brissac was born in San Jose, California and later raised in San Francisco. She was the daughter of B. F. Brissac, a well-to-do Bay Area insurance executive, and was said to be a niece of the actress Mary Shaw. As a young girl she began a collection of autographs that would grow to include such notables as Sarah Bernhardt, Eleonora Duse, Richard Mansfield, Henry Irving and Rudyard Kipling. By 1902 Brissac was a lead player at San Francisco’s Fischer’s Theatre opposite the Bay area actor Reginald Travers (c. 1879-1952). In September of that year the two performed at a church benefit in a specialty act billed as Reginald and Virginia Brissac Travers. A month later they starred together at Fischer’s Theatre in a hit farce entitled, A Pair of Lunatics. After his death in San Francisco nearly fifty years later, Travers was described by The New York Times as a pioneer little theatre impresario and civic leader. In February, 1903 Brissac was with Ralph Stuart’s company playing Constance in a stage adaptation of The Three Musketeers at the Theatre Republic in San Francisco and that September she appeared with Florence Roberts at the Alcazar Theatre performing ingénue roles  in Welcome Home and D’Annuzio’s Gioconda. After touring with Robert’s company Brissac appeared in June, 1904 at the Alcazar with White Whittlesey in Soldier of Fortune and again that August in Clyde Fitch’s, Nathan Hale. In the fall of 1905 Brissac played Caroline Mitford in the William Gillette play, Secret Service and that December the title role in Leo Ditrichstein’s Vivian’s Pappas, both staged at the old Belasco Theatre, Los Angeles. The following February she was declared a hit by a Los Angeles newspaper for her portrayal of Tweeny at the Mason Opera House in Paul Kester’s Sweet Nell of Old Drury.

In July, 1906, Brissac married Eugene D. Mockbee, an actor with the Belasco players. The couple moved to Spokane, Washington, where on October 28, 1907 their only child, Ardel Mockbee, later known as Ardel Wray, was born. A few years later, in May, 1912 Brissac obtained a divorce from Mockbee, on grounds of failure to provide, and was awarded custody of their daughter. Ardel Wray (1907-1983) later became a Hollywood screenwriter remembered for such films as I Walked With a Zombie, The Leopard Man and Isle of the Dead. By the fall of 1906 Brissac was once again with Florence Roberts’ company touring Eastern venues in The Strength of the Weak, a play by Alice M. Smith and Charlotte Thompson. By the end of 1906 Roberts’ company was touring the Pacific Northwest. By Spring, 1907 Brissac had joined the Jessie Shirley Company at the Auditorium Theatre in Spokane, Washington, with whom she would appear in productions of Lady Windermere’s Fan, A Bachelor’s Housekeeper, A Man of Her Choice, The Two Orphans and The Triumph of Betty. For the 1907/08 season she joined the Curtiss Comedy Company at Spokane’s Columbia Theatre performing leading rôles in The Life of an Actress, In the Palace of the King, The Transgressors, By Right of Sword, Ten Nights in a Bar-Room, Deadwood Dick’s Last Shot. The Banker, the Thief and the Girl, Old Heidelberg and The Land of Cotton. By May, 1908 Brissac was appearing with Grant Churchill in a vaudeville act at the Pantages Theatre, Spokane in a piece called The Billionaire. On May 11 she opened Spokane’s new Natatorium Park theatre with her husband, Eugene Mockbee, a frequent co-star during their time in Spokane. Billed as Miss Virginia Brissac and Summer Stock Company, they filled out the remainder of the 1908 season there in productions of Sweet Clover, Troubles, Where Men are Game, School Days, Kathleen of Erin and Home Sweet Home. Brissac apparently chose to leave the stage after her finale engagement in June, 1908 and did not return to it until March, 1911.

Brissac returned to the Alcazar on March 20, 1911 supporting Max Figman in Mary Jane’s Pa. Three months later she starred in the Hal Reid play, Human Hearts, at the Seattle Theatre, Seattle, Washington. and that July opened in Tacoma, Washington starring in A Yankee Doodle Boy with the Pringle Stock Company’s engagement at the Tacoma Theatre. In late 1912 Brissac joined the World’s Fair Stock Company and toured the Hawaiian Islands for a year or so, working with her future husband John Griffith Wray, a lead actor and stage director with the World’s Fair Stock Company and a future MGM film director. Brissac opened at Honolulu’s Bijou Theatre in Brewster’s Millions on December 21, 1912 and closed her Hawaiian tour toward the end of 1913 with their finale performance in Honolulu coming on October 21 at the Grand Opera House. During their time in Hawaii Brissac and Wray made at least two short silent films together, The Shark God and Hawaiian Love, both directed by Wray. Brissac sailed home to San Francisco on January 28, 1914 aboard the steamship Wilhelmina. Brissac and Wray married in Santa Ana, California on June 29, 1915. They divorced in May, 1927, some two years before Wray’s untimely death. Brissac remained active in primarily Bay Area theater for several more seasons. Perhaps her last stage performance, billed as a “Finale Farewell”, came at the Bishop Playhouse, Oakland, California on August 5, 1917 starring in The Eternal Magdalene.

Sometime after her divorce from Wray, Brissac served as a private secretary and assistant to the entertainer Russ Columbo until his death on September 2, 1934. Columbo died following a freak accident involving a friend’s antique dueling pistol. Brissac was later called upon by the Los Angeles County Coroner’s Office to testify and identify Columbo’s remains at the subsequent inquest. Brissac returned to film as Mrs. Van Twerp in the 1935 comedy Honeymoon Limited. Over her career she performed in over 155 big and small screen productions in mostly supporting and minor parts. During what is considered the American Golden Age of Television Brissac appeared in episodes of Dragnet, The Pepsi-Cola Playhouse, I Love Lucy, Crown Theatre with Gloria Swanson, Mayor of the Town (1954 series based on the 1940s radio show) and The Lone Wolf. Brissac retired in 1955 after filming Rebel Without a Cause and died nearly 25 years later in 1979 at the age of 96 in Santa Fe, New Mexico.