Sinclair Lewis’s earliest published creative work—romantic poetry and short sketches—appeared in the Yale Courant and the Yale Literary Magazine, of which he became an editor. After graduation Lewis moved from job to job and from place to place in an effort to make ends meet, write fiction for publication and to chase away boredom. While working for newspapers and publishing houses (and for a time at the Carmel-by-the-Sea, California writers’ colony), he developed a facility for turning out shallow, popular stories that were purchased by a variety of magazines. He also earned money by selling plots to Jack London, including one for the latter’s unfinished novel The Assassination Bureau, Ltd. Lewis’s first published book was Hike and the Aeroplane, a Tom Swift-style potboiler that appeared in 1912 under the pseudonym Tom Graham. Sinclair Lewis’s first serious novel, Our Mr. Wrenn: The Romantic Adventures of a Gentle Man, appeared in 1914, followed by The Trail of the Hawk: A Comedy of the Seriousness of Life (1915) and The Job (1917). That same year also saw the publication of another potboiler, The Innocents: A Story for Lovers, an expanded version of a serial story that had originally appeared in Woman’s Home Companion. Free Air, another refurbished serial story, was published in 1919. Upon moving to Washington, D.C., Sinclair Lewis devoted himself to writing. As early as 1916, he began taking notes for a realistic novel about small-town life. Work on that novel continued through mid-1920, when he completed Main Street, which was published on October 23, 1920. As his biographer Mark Schorer wrote, the phenomenal success of Main Street “was the most sensational event in twentieth-century American publishing history.” Sinclair Lewis’s agent had the most optimistic projection of sales at 25,000 copies. In its first six months, Main Street sold 180,000 copies, and within a few years, sales were estimated at two million. According to biographer Richard Lingeman, “Main Street made [Lewis] rich—earning him perhaps three million current [2005] dollars”.

Sinclair Lewis followed up this first great success with Babbitt (1922), a novel that satirized the American commercial culture and boosterism. The story was set in the fictional Midwestern town of Zenith, Winnemac, a setting to which Lewis would return in future novels, including Gideon Planish and Dodsworth. Lewis continued his success in the 1920s with Arrowsmith (1925), a novel about the challenges faced by an idealistic doctor. It was awarded the Pulitzer Prize, which Lewis declined. Adapted as a 1931 Hollywood film directed by John Ford and starring Ronald Colman, it was nominated for four Academy Awards. Next Lewis published Elmer Gantry (1927), which depicted an evangelical minister as deeply hypocritical. The novel was denounced by many religious leaders and banned in some U.S. cities. Adapted for the screen more than a generation later, the novel was the basis of the 1960 movie starring Burt Lancaster, who earned a Best Actor Oscar for his performance. Sinclair Lewis next published Dodsworth (1929), a novel about the most affluent and successful members of American society. He portrayed them as leading essentially pointless lives in spite of great wealth and advantages. The book was adapted for the Broadway stage in 1934 by Sidney Howard, who also wrote the screenplay for the 1936 film version. Directed by William Wyler and a great success at the time, the film is still highly regarded. In 1990, it was selected for preservation in the United States National Film Registry, and in 2005 Time magazine named it one of the “100 Best Movies” of the past 80 years. During the late 1920s and 1930s, Lewis wrote many short stories for a variety of magazines and publications. “Little Bear Bongo” (1930), a tale about a bear cub who wanted to escape the circus in search of a better life in the real world, was published in Cosmopolitan magazine. The story was acquired by Walt Disney Pictures in 1940 for a possible feature film. World War II sidetracked those plans until 1947. Disney used the story (now titled “Bongo”) as part of its feature Fun and Fancy Free.

In 1930, Lewis won the Nobel Prize in Literature, the first writer from the United States to receive the award, after he had been nominated by Henrik Schück, member of the Swedish Academy. In the Academy’s presentation speech, special attention was paid to Babbitt. In his Nobel Lecture, Lewis praised Theodore Dreiser, Willa Cather, Ernest Hemingway, and other contemporaries, but also lamented that “in America most of us—not readers alone, but even writers—are still afraid of any literature which is not a glorification of everything American, a glorification of our faults as well as our virtues,” and that America is “the most contradictory, the most depressing, the most stirring, of any land in the world today.” He also offered a profound criticism of the American literary establishment: “Our American professors like their literature clear and cold and pure and very dead.” After winning the Nobel Prize, Lewis wrote eleven more novels, ten of which appeared in his lifetime. The best remembered is It Can’t Happen Here (1935), a novel about the election of a fascist to the American presidency. After an alcoholic binge in 1937, Lewis checked into the Austen Riggs Center, a psychiatric hospital in Stockbridge, Massachusetts, for treatment. His doctors gave Lewis a blunt assessment that he needed to decide “whether he was going to live without alcohol or die by it, one or the other.” Lewis checked out after ten days, lacking, one of his physicians wrote to a colleague, any “fundamental understanding of his problem.”

In the 1940s, Lewis and rabbi-turned-popular author Lewis Browne frequently appeared on the lecture platform together, touring the United States and debating such questions as “Has the Modern Woman Made Good?”, “The Country Versus the City”, “Is the Machine Age Wrecking Civilization?” and “Can Fascism Happen Here?” before audiences of as many as 3,000 people. The pair was described as “the Gallagher and Shean of the lecture circuit” by Lewis biographer Richard Lingeman. The novel Kingsblood Royal (1947) is set in the fictional city Grand Republic, Minnesota, an enlarged and updated version of Zenith. Based on the Sweet Trials in Detroit, in which an African-American doctor was denied the chance to purchase a house in a “white” section of the city, Kingsblood Royal was a powerful and very early contribution to the civil rights movement. In 1946, Sinclair Lewis who had been a frequent visitor to Williamstown, Massachusetts, rented Thorvale Farm on Oblong Road. While working on his novel, Kings Blood Royal, he purchased this summer estate and upgraded the Georgian mansion along with a farmhouse and many outbuildings. By 1948 Lewis had created a gentleman’s farm consisting of 720 acres of agricultural and forest land. His intended residence in Williamstown was short-lived because of his medical problems. Lewis died in Rome on January 10, 1951, aged 65, from advanced alcoholism. His body was cremated and his remains were buried in Sauk Centre. A final novel, World So Wide (1951), was published posthumously. William Shirer, a friend and admirer of Lewis, disputes accounts that Lewis died of alcoholism per se. He reported that Lewis had a heart attack and that his doctors advised him to stop drinking if he wanted to live. Lewis did not, and perhaps could not, stop; he died when his heart stopped.