Battle made her television debut in 2006, having small roles on shows including Zoey 101 and Everybody Hates Chris. In 2010, Battle was a background dancer in the Cali Swag District music video “Teach Me How to Dougie”.  In 2011, Battle auditioned for the American singing competition The X Factor in front of judges Simon Cowell, Paula Abdul, Cheryl Cole and L.A. Reid. Battle sang “When I Grow Up” by The Pussycat Dolls. After receiving three yeses from the judges, Battle had made it through to Bootcamp. She was mentored by Cowell after becoming one of the Top 32 finalists in the girls category. Battle was chosen to be part of the live shows with Melanie Amaro, Rachel Crow, Drew, and Tiah Tolliver. After making it to the top 17, Battle and Tolliver were eliminated from the girls category during the first week by Cowell.

In 2012, Battle starred opposite Mandela Van Peebles, Moisés Arias, and Snoop Dogg in her film debut “We the Party”. The film received mixed to positive reviews from critics. We the Party was Simone’s first and final full length film. In 2012, Battle played Olivia in the short film “Meanamorphosis” The film was released on April 27, 2012.  Upon Steve Jones’ announcement that she had been eliminated from the competition, Battle promoted the online release of her debut music video “He Likes Boys”.  In August 2012, Simone Battle was initially part of The Pussycat Dolls’ proposed new line-up after their past members disbanded in 2010. Her addition to the group was announced during the opening of the Pussycat Dolls Dollhouse at the Keating Hotel in San Diego. Robin Antin later announced on February 2013 that they would continue instead as the “next generation” of the Dolls as a group called G.R.L.

Battle was found dead at her Los Angeles home at about 8 a.m. on September 5, 2014, at the age of 25. She hung herself. The cause of her death is under investigation. Her death has been reported as a suicide. A spokesperson for Battle stated that she suffered from depression due to financial issues.