Clooney was born in Maysville, Kentucky, the daughter of Marie Frances (née Guilfoyle) and Andrew Joseph Clooney. She was one of five children. Her father was of Irish and German descent and her mother was of Irish and English ancestry. She was raised Catholic. When Clooney was 15, her mother and brother Nick moved to California. She and her sister Betty remained with their father.[citation needed] The family resided in the John Brett Richeson House in the late 1940s. Rosemary and Betty became entertainers, whereas Nick became a newsman and television broadcaster (some of her children, including Miguel Ferrer and Rafael Ferrer, and her nephew, George Clooney, also became respected actors and entertainers). In 1945, the Clooney sisters won a spot on Cincinnati, Ohio’s radio station WLW as singers. Her sister Betty sang in a duo with Rosemary for much of the latter’s early career. Clooney’s first recordings, in May 1946, were for Columbia Records. She sang with Tony Pastor’s big band. Clooney continued working with the Pastor band until 1949, making her last recording with the band in May of that year and her first as a solo artist a month later, still for Columbia. In 1950-51 she was a regular on the radio and television versions of “Songs For Sale” on CBS. In 1951, her record of “Come On-a My House”, produced by Mitch Miller, became a hit. It was her first of many singles to hit the charts—despite the fact that Clooney hated the song passionately. She had been told by Columbia Records to record the song, and that she would be in violation of her contract if she did not do so. Clooney recorded several duets with Marlene Dietrich and appeared in the early 1950s on Faye Emerson’s Wonderful Town series on CBS. Clooney also did several guest appearances on the Arthur Godfrey radio show, when it was sponsored by Lipton Tea. They did duets as he played his ukulele, and other times she would sing one of her latest hits.

In 1954, she starred, along with Bing Crosby, Danny Kaye, and Vera-Ellen, in the movie White Christmas. She starred, in 1956, in a half-hour syndicated television musical-variety show The Rosemary Clooney Show. The show featured The Hi-Lo’s singing group and Nelson Riddle’s orchestra. The following year, the show moved to NBC prime time as The Lux Show Starring Rosemary Clooney but only lasted one season. The new show featured the singing group The Modernaires and Frank DeVol’s orchestra. In later years, Clooney would often appear with Bing Crosby on television, such as in the 1957 special The Edsel Show, and the two friends made a concert tour of Ireland together. On November 21, 1957, she appeared on NBC’s The Ford Show, Starring Tennessee Ernie Ford, a frequent entry in the “Top 20” and featuring a musical group called “The Top Twenty.” In 1960, Clooney and Crosby co-starred in a 20-minute CBS radio program aired before the midday news each weekday. Clooney left Columbia Records in 1958, doing a number of recordings for MGM Records and then some for Coral Records. Finally, toward the end of 1958, she signed with RCA Victor Records, where she stayed until 1963. In 1964, she went to Reprise Records, and in 1965 to Dot Records.

Upon her recovery from a nervous breakdown in 1968, Clooney signed with United Artists Records in 1976 for two albums. Beginning in 1977, she recorded an album a year for the Concord Jazz record label, which continued until her death. This was in contrast to most of her generation of singers who had long since stopped recording regularly by then. In the late 1970s and early 1980s, Clooney did television commercials for Coronet brand paper towels, during which she sang a memorable jingle that goes, “Extra value is what you get, when you buy Coro-net.” In the early 1980s, Jim Belushi parodied Clooney and the commercial on NBC’s Saturday Night Live. Clooney sang a duet with Wild Man Fischer on “It’s a Hard Business” in 1986, and in 1994 she sang a duet of Green Eyes with Barry Manilow in his 1994 album, Singin’ with the Big Bands. In 1995, Clooney guest-starred in the NBC television medical drama ER (starring her nephew, George Clooney); for her performance, she received a Primetime Emmy Award nomination for Outstanding Guest Actress in a Drama Series. On January 27, 1996, Clooney appeared on Garrison Keillor’s Prairie Home Companion radio program. She sang “When October Goes”—lyrics by Johnny Mercer and music by Barry Manilow (after Mercer’s death)—from Manilow’s 1984 album 2:00 AM Paradise Cafe, and discussed the excellence of Manilow the musician. Clooney was also awarded Society of Singers Lifetime Achievement Award in 1998.[4] In 1999, she founded the Rosemary Clooney Music Festival, held annually in Maysville, her hometown. She performed at the festival every year until her death. Proceeds benefit the restoration of the Russell Theater in Maysville, where Clooney’s first film, The Stars Are Singing, premiered in 1953. She received the Grammy Lifetime Achievement Award in 2002.

A long-time smoker, Clooney was diagnosed with lung cancer at the end of 2001. Around this time, she gave one of her last concerts in Hawaii, backed by the Honolulu Symphony Pops; her last song was “God Bless America”. Her final show was at Red Bank New Jersey”s Count Basie Theater in December 2001. Despite surgery, she died six months later on June 29, 2002, at her Beverly Hills home. Her nephew, George Clooney, was a pallbearer at her funeral, which was attended by numerous stars, including Al Pacino. She is buried at Saint Patrick’s Cemetery, Maysville. In 2003, Rosemary Clooney was inducted into the Kentucky Women Remembered exhibit and her portrait by Alison Lyne is on permanent display in the Kentucky State Capitol’s rotunda. In September 2007, a mural honoring moments from her life was painted in downtown Maysville. The mural highlights her lifelong friendship with Blanche Chambers, the 1953 premier of The Stars are Singing and her singing career. It was painted by Louisiana muralists Robert Dafford, Herb Roe and Brett Chigoy as part of the Maysville Floodwall Murals project. Her brother Nick Clooney spoke during the dedication for the mural, explaining various images to the crowd.