Norman Shumway was born in Kalamazoo, Michigan. He attended the University of Michigan for one year as an undergraduate until he was drafted by the Army in 1943, which sent him to John Tarleton Agricultural College in Stephenville, Texas for engineering training. He then underwent Army Specialized Training, which included nine months of pre-medical training at Baylor University, followed by enrollment at Vanderbilt University for medical school. He received his M.D. from Vanderbilt in 1949. He did his residency at the University of Minnesota under Walt Lillehei alongside future fellow transplantation pioneer Christiaan Barnard, and was awarded a surgical doctorate in 1956. In 1958, he began working as an instructor in surgery at Stanford Hospital in San Francisco, California, and later, in Palo Alto when the hospital was moved. Norman Shumway spent many years training promising young residents of cardiology and cardiothoracic surgery at Stanford University. Among his notable trainees is Stanford cardiologist Hannah Valantine, a native of Gambia who was appointed in 2014 as the U.S. National Institutes of Health Chief Officer for Scientific Workforce Diversity. In collaboration with Randall B. Griepp, he was the first doctor to successfully carry out a now adult human heart transplant operation in the United States in 1968, after Barnard’s 1967 operation in South Africa, which was based upon the work of Shumway and Richard Lower. The early years of the procedure were difficult, with few patients surviving for long. Shumway was the only American surgeon to continue performing the operation after others abandoned it after poor results. In the 1970s he and his team refined the operation, tackling the problems of rejection and the necessity for potentially dangerous drugs to suppress the immune system. In particular he pioneered the use of cyclosporine, instead of traditional drugs, which made the operation safer.