By the mid-1920s, Jimmy Durante had become a vaudeville star and radio personality in a trio called Clayton, Jackson and Durante. Lou Clayton and Eddie Jackson, Durante’s closest friends, often reunited with Durante in subsequent years. Jackson and Durante appeared in the Cole Porter musical The New Yorkers, which opened on Broadway on December 8, 1930. Earlier that same year, the team appeared in the movie Roadhouse Nights, ostensibly based on Dashiell Hammett’s novel Red Harvest. By 1934, Durante had a major record hit with his own novelty composition, “Inka Dinka Doo”, with lyrics by Ben Ryan. It became his theme song for the rest of his life. A year later, Durante starred on Broadway in the Billy Rose stage musical Jumbo. A scene in which a police officer stopped Durante’s character—who was leading a live elephant across the stage—to ask, “What are you doing with that elephant?”, followed by Durante’s reply, “What elephant?”, was a regular show-stopper. This comedy bit, also reprised in his role in Billy Rose’s Jumbo, likely contributed to the popularity of the idiom the elephant in the room. Durante also appeared on Broadway in Show Girl (1929), Strike Me Pink (1934) and Red, Hot and Blue (1936).

Jimmy Durante began appearing in motion pictures, initially in a series pairing him with silent film legend Buster Keaton. The three popular comedies Speak Easily (1932), The Passionate Plumber (1932), and What! No Beer? (1933) were financial hits and were a career springboard for Durante. However, Keaton’s vociferous dissatisfaction with constraints the studio had placed upon him, exacerbated by his alcoholism, led MGM to end the series. Durante went on to appear in The Wet Parade (1932), Broadway to Hollywood (1933), The Man Who Came to Dinner (1942, playing Banjo, a character based on Harpo Marx), Ziegfeld Follies (1946), Billy Rose’s Jumbo (1962, based on the 1935 musical), and It’s a Mad, Mad, Mad, Mad World (1963). In 1934, he starred in Hollywood Party, where he dreams he is ‘Schnarzan’—a parody of ‘Tarzan’, who was extremely popular at the time due to the Johnny Weissmuller films.

On September 10, 1933, Jimmy Durante appeared on Eddie Cantor’s NBC radio show, The Chase and Sanborn Hour, continuing until November 12 of that year. When Cantor left the show, Durante took over as its star from April 22 to September 30, 1934. He then moved on to The Jumbo Fire Chief Program (1935–36). Durante teamed with Garry Moore for The Durante-Moore Show in 1943. Durante’s comic chemistry with the young, brushcut Moore brought Durante an even larger audience. “Dat’s my boy dat said dat!” became an instant catchphrase. The duo was one of the nation’s favorites for the rest of the decade. Their Armed Forces Radio Network command performance with Frank Sinatra remains a favorite of radio-show collectors today. Moore left the duo in mid-1947, and the program returned October 1, 1947 as The Jimmy Durante Show. Durante continued the show for three more years, and featured a reunion of Clayton, Jackson and Durante on his April 21, 1948 broadcast.

Jimmy Durante made his television debut on November 1, 1950 (although he kept a presence in radio, as a frequent guest on Tallulah Bankhead’s two-year NBC comedy-variety show The Big Show). Durante was one of the cast on the show’s premiere November 5, 1950. The rest of the cast included humorist Fred Allen, singers Mindy Carson and Frankie Laine, stage musical performer Ethel Merman, actors Jose Ferrer and Paul Lukas, and comic-singer Danny Thomas (about to become a major television star in his own right). A highlight of the show was Durante and Thomas, whose own nose rivaled Durante’s, in a routine in which Durante accused Thomas of stealing his nose. “Stay outta dis, No-Nose!” Durante barked at Bankhead to a big laugh. From 1950 to 1951, Durante was one of four alternating hosts on NBC’s comedy-variety series Four Star Revue. He alternated Wednesdays with Danny Thomas (now a headliner), Jack Carson, and Ed Wynn. Beginning in the early 1950s, Durante teamed with sidekick Sonny King, a collaboration that would continue until Durante’s death. Jimmy could be seen regularly in Las Vegas after Sunday Mass outside of the Guardian Angel Cathedral standing next to the priest and greeting the people as they left Mass. His last regular television appearance was co-starring with the Lennon Sisters on “Jimmy Durante Presents the Lennon Sisters Hour” which lasted for one season on ABC (1969-1970). Jimmy Durante retired from performing in 1972 after he became a wheelchair user following a stroke. He died of pneumonia in Santa Monica, California, on January 29, 1980. He received Roman Catholic funeral rites four days later, with fellow entertainers including Desi Arnaz, Ernest Borgnine, Marty Allen, and Jack Carter in attendance, and was interred at Holy Cross Cemetery, Culver City.