Ernst Mayr was the second son of Helene Pusinelli and Dr. Otto Mayr. His father was a jurist (District Prosecuting Attorney at Würzburg)[4] but took an interest in natural history and took the children out on field trips. He learnt all the local birds in Würzburg from his elder brother Otto. He also had access to a natural history magazine for amateurs, Kosmos. His father died just before he was thirteen. The family then moved to Dresden and he studied at the Staatsgymnasium (“Royal Gymnasium” until 1918) in Dresden-Neustadt and completed his high school education there. In April 1922, while still in high school, he joined the newly founded Saxony Ornithologists’ Association. Here he met Rudolf Zimmermann, who became his ornithological mentor. In February 1923, Mayr passed his high school examination (Abitur) and his mother rewarded him with a pair of binoculars. On 23 March 1923 on the lakes of Moritzburg, the Frauenteich, he spotted what he identified as a red-crested pochard. The species had not been seen in Saxony since 1845 and the local club argued about the identity. Raimund Schelcher (1891–1979) of the club then suggested that Mayr visit his classmate Erwin Stresemann on his way to Greifswald, where Mayr was to begin his medical studies. After a tough interrogation, Stresemann accepted and published the sighting as authentic. Stresemann was very impressed and suggested that, between semesters, Mayr could work as a volunteer in the ornithological section of the museum. Ernst Mayr wrote about this event, “It was as if someone had given me the key to heaven.” He entered the University of Greifswald in 1923 and, according to Mayr himself, “took the medical curriculum (to satisfy a family tradition) but after only a year, he decided to leave medicine and enrolled at the Faculty of Biological Sciences.” Ernst Mayr was endlessly interested in ornithology and “chose Greifswald at the Baltic for my studies for no other reason than that … it was situated in the ornithologically most interesting area.” Although he ostensibly planned to become a physician, he was “first and foremost an ornithologist.” During the first semester break Stresemann gave him a test to identify treecreepers and Mayr was able to identify most of the specimens correctly. Stresemann declared that Mayr “was a born systematist”. In 1925, Stresemann suggested that he give up his medical studies, in fact he should leave the faculty of medicine and enrol into the faculty of Biology and then join the Berlin Museum with the prospect of bird-collecting trips to the tropics, on the condition that he completed his doctoral studies in 16 months. Mayr completed his doctorate in ornithology at the University of Berlin under Dr. Carl Zimmer, who was a full professor (Ordentlicher Professor), on 24 June 1926 at the age of 21. On 1 July he accepted the position offered to him at the museum for a monthly salary of 330.54 Reichsmark.

At the International Zoological Congress at Budapest in 1927, Mayr was introduced by Stresemann to banker and naturalist Walter Rothschild, who asked him to undertake an expedition to New Guinea on behalf of himself and the American Museum of Natural History in New York. In New Guinea, Ernst Mayr collected several thousand bird skins (he named 26 new bird species during his lifetime) and, in the process also named 38 new orchid species. During his stay in New Guinea, he was invited to accompany the Whitney South Seas Expedition to the Solomon Islands. Also, while in New Guinea, he visited the Lutheran missionaries Otto Thiele and Christian Keyser, in the Finschhafen district; there, while in conversation with his hosts, he uncovered the discrepancies in Hermann Detzner’s popular book Four Years Among the Cannibals in German Guinea from 1914 to the Truce, in which Detzner claimed to have seen the interior, discovered several species of flora and fauna, while remaining only steps ahead of the Australian patrols sent to capture him. He returned to Germany in 1930, and in 1931 he accepted a curatorial position at the American Museum of Natural History, where he played the important role of brokering and acquiring the Walter Rothschild collection of bird skins, which was being sold in order to pay off a blackmailer. During his time at the museum he produced numerous publications on bird taxonomy, and in 1942 his first book Systematics and the Origin of Species, which completed the evolutionary synthesis started by Darwin. After Mayr was appointed at the American Museum of Natural History, he influenced American ornithological research by mentoring young birdwatchers. Mayr was surprised at the differences between American and German birding societies. He noted that the German society was “far more scientific, far more interested in life histories and breeding bird species, as well as in reports on recent literature.”

Ernst Mayr organized a monthly seminar under the auspices of the Linnean Society of New York. Under the influence of J.A. Allen, Frank Chapman, and Jonathan Dwight, the society concentrated on taxonomy and later became a clearing house for bird banding and sight records. Mayr encouraged his Linnaean Society seminar participants to take up a specific research project of their own. Under Mayr’s influence one of them, Joseph Hickey, went on to write A Guide to Birdwatching (1943). Hickey remembered later, “Mayr was our age and invited on all our field trips. The heckling of this German foreigner was tremendous, but he gave tit for tat, and any modern picture of Dr E. Mayr as a very formal person does not square with my memory of the 1930s. He held his own.” A group of eight young birdwatchers from The Bronx later became the Bronx County Bird Club, led by Ludlow Griscom. “Everyone should have a problem” was the way one Bronx County Bird Club member recalled Mayr’s refrain. Mayr said of his own involvement with the local birdwatchers: “In those early years in New York when I was a stranger in a big city, it was the companionship and later friendship which I was offered in the Linnean Society that was the most important thing in my life.” Ernst Mayr also greatly influenced the American ornithologist Margaret Morse Nice. Mayr encouraged her to correspond with European ornithologists and helped her in her landmark study on song sparrows. Nice wrote to Joseph Grinnell in 1932, trying to get foreign literature reviewed in the Condor: “Too many American ornithologists have despised the study of the living bird; the magazines and books that deal with the subject abound in careless statements, anthropomorphic interpretations, repetition of ancient errors, and sweeping conclusions from a pitiful array of facts. … in Europe the study of the living bird is taken seriously. We could learn a great deal from their writing.” Mayr ensured that Nice could publish her two-volume Studies in the Life History of the Song Sparrow. He found her a publisher, and her book was reviewed by Aldo Leopold, Joseph Grinnell, and Jean Delacour. Nice dedicated her book to “My Friend Ernst Mayr.”

Mayr joined the faculty of Harvard University in 1953, where he also served as director of the Museum of Comparative Zoology from 1961 to 1970. He retired in 1975 as emeritus professor of zoology, showered with honors. Following his retirement, he went on to publish more than 200 articles, in a variety of journals—more than some reputable scientists publish in their entire careers; 14 of his 25 books were published after he was 65. Even as a centenarian, he continued to write books. On his 100th birthday, he was interviewed by Scientific American magazine. Ernst Mayr died on 3 February 2005 in his retirement home in Bedford, Massachusetts after a short illness. His wife, Margarete, died in 1990. He was survived by two daughters, five grandchildren and 10 great-grandchildren.