By the age of 17, Elizabeth Murphy was playing professionally and demanding to be paid when she played. She first signed with the Providence Independents and then  in 1918 she signed with Ed Carr’s Traveling All-Stars, a semi-professional team out of Boston. Carr’s was a barnstorming team which traveled throughout Canada and New England playing up to 100 games a year. She also played in the women’s leagues, playing for the Bloomer Girls for 30 years. When she began her professional career, she was a pitcher, but she was also known as a hitter. Her career average upon retirement was .300. Elizabeth Murphy was keen on self-promotion, selling photographs of herself between innings. She billed herself as the “Queen of Baseball” but was known as Spike Murphy. Newspapers recognized her skill and rather than bill her as a woman player on the team, she was called by name, as a publicity draw in headlines like, “Lizzie Murphy in Game”, “Tyler Will Hurl Against Lizzie Murphys Tomorrow”, and “‘Spike’ Murphy, Woman Baseball Wizard, Learned Game Throwing Stones—‘Ty’ and ‘Babe’ Better Beware if “Liz” Breaks Into Game”.

Elizabeth Murphy usually played first base and made history in 1922 as the first female player to play against major league players. The game was a charity exhibition pitting all-star players from the New England and American Leagues against the Boston Red Sox. It was organized at Fenway Park to raise money for the family of Tommy McCarthy aka “Little Mac”, who had recently died. McCarthy would later be inducted into the Baseball Hall of Fame. She came in to the game in the fourth inning and scored an out at first base from a throw by third baseman Harvey McClellan. Six years later, Murphy played in a Nationals League All-Star game against the Boston Braves and she played in a Negro League game against one of the greatest pitchers in the Negro League Satchel Paige. During the game Murphy was able to get a base hit and after the game Satchel was asked if he had pitched more gently because she was a lady. Josh Gibson the (catcher) refuted the claim, stating Page had treated her the same as any other player. In addition to playing against the negro league, Murphy played for them. When the Cleveland Giants toured in Rhode Island, she played first base for them, becoming the first female to play in that league as well. Murphy was the only female to play for both the American and National League and the Negro Leagues. Elizabeth Murphy retired in 1935, went back home to Warren, and then married Walter Larivee in 1937. When her husband died a few years later, Murphy went back to work in the woolen mills and worked on oyster boats. She died on July 27, 1964. Murphy was inducted into the Rhode Island Heritage Hall of Fame in 1994.