Mary Elizabeth Anania, the daughter of Mary Elizabeth Thweatt Anania (March 11, 1923 – January 25, 2012) and Vincent Anania (April 22, 1920 – March 1, 2008), grew up in a military family, moving many times and never having a hometown. Her father, a United States Navy pilot, was transferred from military base to military base during her childhood and adolescence; for part of her childhood, she lived in Japan, where her father was stationed. She relates in her book Saving Graces that one of the difficult relocations that she went through was moving during her senior year of high school. Some of her childhood friends’ fathers were killed in war and Edwards relates childhood memories of attending their funerals. She also relates the stress of living at a military base with hospital facilities that handled a constant stream of wounded soldiers while her father was away fighting in Vietnam.

Edwards had two younger siblings: a brother, Jay Anania, a professor of film at New York University and a sister, Nancy Anania. Edwards graduated from the Francis C. Hammond High School in Alexandria, Virginia, then attended Mary Washington College in Fredericksburg, Virginia. She transferred to the University of North Carolina at Chapel Hill (UNC), where she earned a Bachelor’s degree. After three years of postgraduate studies in English, she entered UNC’s School of Law and earned a Juris Doctor.

Edwards began her career as a law clerk for a federal judge, then moved to Nashville, Tennessee, in 1978 to become an associate at the law firm of Harwell Barr Martin & Sloan. In 1981, she and her husband moved their family to Raleigh, where she worked in the Office of the Attorney General, and at the law firm Merriman, Nicholls, and Crampton. She kept the last name Anania until 1996, when she retired from legal practice upon the death of her son and changed her name to Elizabeth Anania Edwards in Wade’s memory. Much of her time after leaving legal practice was devoted to the administration of the Wade Edwards Foundation. She taught legal writing as an adjunct instructor at the University of North Carolina School of Law and worked as a substitute teacher in the Wake County Public Schools. In August 2009, she opened a furniture store in Chapel Hill.

In September 2006, Random House published her first book, Saving Graces: Finding Solace and Strength from Friends and Strangers, focusing on the ways in which various communities have helped her through the trials of her life, from her itinerant military childhood to the death of her son and her early bout with breast cancer. In May 2009, they published her second book, Resilience: Reflections on the Burdens and Gifts of Facing Life’s Adversities, further discussing the return of her illness, the deaths of her father and son, the effect of these events on her marriage, her husband’s infidelity, and the general state of health care in America. Both books are best-sellers.

During much of 2004, Edwards joined her husband and United States Democratic Presidential nominee Senator John Kerry on the nationwide campaign trail. She took a similar role in her husband’s 2008 presidential bid and was considered one of his closest advisers.  Edwards disagreed with her husband on the topic of same-sex marriage. She became a vocal advocate in 2007 when she stated: “I don’t know why someone else’s marriage has anything to do with me. I’m completely comfortable with gay marriage.”  On June 10, 2008, it was revealed that Edwards would be advising her husband’s former rival, and eventual Democratic nominee, Barack Obama, on healthcare issues. Her husband also endorsed Obama during the later stages of the 2008 primary season.  Edwards became a senior fellow at the American Progress Action Fund and testified to Congress about health care reform on their behalf.

Edwards met John Edwards when they were both law students, and they married on July 30, 1977.  Early in their marriage, the couple had two children: Lucius Wade (known as Wade) (born 1979) and Catharine (known as Cate) (born 1982). Wade was killed on April 4, 1996, when he lost control of his Jeep while driving from their home in Raleigh to the family’s beach house near Wilmington. Three weeks before his death, Wade Edwards was honored by First Lady Hillary Rodham Clinton at the White House as one of ten finalists in an essay contest sponsored by the National Endowment for the Humanities and the Voice of America. Wade, accompanied by his parents and his sister, met North Carolina Senator Jesse Helms. After Wade died, Helms entered his essay and his obituary into the Congressional Record.  Following Wade’s death, the Edwardses decided to have more children, and Elizabeth underwent fertility treatments. They had a daughter, Emma Claire (born 1998), and a son, John (known as Jack) (born 2000). After John’s January 21, 2010, public admission that he fathered a child with another woman, Elizabeth legally separated from him, intending to file for divorce after North Carolina’s mandatory one-year separation policy, though she later stated that they had no intent to divorce unless one of them would want to remarry.

On November 3, 2004, the day Kerry conceded defeat in the 2004 U.S. presidential election, Edwards was diagnosed with breast cancer. She later revealed that she discovered a lump in her breast while on a campaign stop in Kenosha, Wisconsin, a few weeks earlier, in the midst of the campaign. Edwards became an activist for women’s health and cancer patients, and underwent oncology treatments. In a November 2006 comment on the Daily Kos website, Edwards stated that on her last visit, her oncologist said that cancer was not one of the things going on in her life.

At a March 22, 2007, press conference, John and Elizabeth Edwards announced that her cancer had returned, and that his campaign for the Presidency would continue as before. The announcement included the information that she was asymptomatic, and therefore that she expected to be an active part of the campaign. Her doctor, Dr. Lisa Carey of the University of North Carolina’s Lineberger Comprehensive Cancer Center, described the diagnosis as stage IV (metastatic) breast cancer with a spot in her rib and possibly her lung. In a March 25 interview on 60 Minutes, Edwards said that there was also a spot in her hip found on her bone scan. The Edwardses and Dr. Carey stressed that the cancer was not curable, but was treatable. In early April 2007, Edwards was informed that her cancer might be treatable with anti-estrogen drugs. “I consider that a good sign. It means there are more medications to which I can expect to be responsive,” she told the Associated Press during a campaign stop with her husband in Cedar Rapids, Iowa. In a 2007 interview with Newsweek’s Jonathan Alter, she said, “When I was first diagnosed, I was going to beat this. I was going to be the champion of cancer. And I don’t have that feeling now. The cancer will eventually kill me. It’s going to win this fight.”

On December 6, 2010, Edwards’ family announced that she had stopped cancer treatment after her doctors advised her that further treatment would be unproductive, the cancer having metastasized to her liver. She had been advised she had several weeks to live. Her family members, including her estranged husband John, were with her.  Edwards died of metastatic breast cancer the next day, on December 7, 2010, at home in Chapel Hill, surrounded by her family and friends. Her funeral, held at Edenton Street United Methodist Church in Raleigh, was open to the public and was attended by over 1,200 people, including North Carolina Governor Beverly Perdue, Senators John Kerry and Kay Hagan, and Victoria Reggie Kennedy. Threats of protests by the anti-gay “hate-group” Westboro Baptist Church attracted at least 300 local Raleigh residents prepared to counterprotest in support of the Edwards family, but only five Westboro protesters showed up and were kept blocks away. Edwards was buried in Historic Oakwood Cemetery next to her son Wade.