Her first screen appearance was at the age of 10, when she appeared briefly in Frank Capra’s It Happened One Night. According to Fuller[citation needed], the female lead in Bride of the Monster was written for her but Wood gave it to Loretta King instead. In August 1954, Fuller was cast in Wood’s The Vampire’s Tomb, intended to star Bela Lugosi. Frank Yaconelli was named as her co-star and ‘comic killer’. The film was never made. She ended up making an appearance in Bride of the Monster (1956), also with Lugosi. Dolores Fuller hosted a benefit for Lugosi which preceded the showing of Bride of the Atom (early working title of Bride of the Monster) on May 11, 1955. A cocktail party was held at the Gardens Restaurant at 4311 Magnolia Avenue in Burbank, California. Vampira attended and was escorted by Paul Marco. A single screening of the film was presented at the Hollywood Paramount. According to Dolores Fuller, as quoted in Wood biography Nightmare of Ecstasy (1992), she first met Ed Wood when she attended a casting call with a friend for a movie he was supposed to direct called Behind Locked Doors; it has also been stated that they met in a restaurant. Dolores Fuller became his girlfriend shortly thereafter and began acting in his films. Her movie career included a bit part in It Happened One Night (1934) and roles in Outlaw Women (1952), Glen or Glenda (1953), Body Beautiful (1953), The Blue Gardenia (1953), Count the Hours (1953), Mesa of Lost Women (1953), College Capers (1954), Jail Bait (1954), The Raid (1954), This Is My Love (1954), The Opposite Sex (1956), The Ironbound Vampire (1997), and Dimensions in Fear (1998).

Dolores Fuller had already had earlier experience on television in Queen for a Day and The Dinah Shore Show. As Fuller remembered, she was the one “putting bread on the table.” Another quote from her: “I had a size four and a half foot, so I modeled the slippers in an artist’s short smock.” She lost her job on The Dinah Shore Show when, as she said, “We were shooting all night, and into the next day, and time just got away from me, and I didn’t realize that I was supposed to be on the set working as Dinah’s double on her show, Chevy Theatre. I completely messed up my job, I was what they called a no show.”[this quote needs a citation] She also appeared on an episode of It’s a Great Life as “the blonde in the mink coat.” Fuller’s ability as a songwriter manifested itself through the intervention of her friend, producer Hal Wallis; Fuller had wanted to get an acting role in the Elvis Presley movie Blue Hawaii, which Wallis was producing, but instead he put her in touch with Hill & Range, the publisher that provided Presley with songs. Fuller went into a collaborative partnership with composer Ben Weisman and co-wrote one song, “Rock-A-Hula Baby”, for the film. It was a beginning that eventually led to Elvis Presley recording a dozen of her songs, including “I Got Lucky” and “Spinout”. Fuller also had her music recorded by Nat ‘King’ Cole, Peggy Lee, and other leading talents of the time.