Cookie Mueller grew up with her parents Frank Lennert Mueller (d. 1984) and Anne (Sawyer) Mueller (d. 1995, aged 82) in the Baltimore suburbs in a house near the woods, a mental hospital and railroad tracks. Mueller had many pets as a child, including many turtles (one named Fidel), a dog named Jip, snakes, and tadpoles. Cookie began to write at age 11, when she wrote a 321-page book about the Johnstown flood of 1889. She stapled it together, wrapped it in butcher paper and Saran wrap, and placed it on the shelves of a local library in what would have been its proper place. The book was never seen again. With a swath of pivotal events in Mueller’s life—including her brother’s death at age 14, the result of climbing a dead tree, which collapsed on him in the woods near their home—she went on to pursue her writing, and in high school hung out with the hippie crowd. One of Mueller’s idiosyncrasies as a teen was that she constantly dyed her hair: “Whenever you’re depressed, just change your hair color,” she always told me, years later, when I was a teenager: I was never denied a bottle of hair bleach or dye. In my closet there weren’t many clothes, but there were tons of bottles.” She took a small job at a Baltimore men’s department store and saved up enough funds to head to Haight-Ashbury, where she continued the hippie lifestyle.

Cookie Mueller traveled across the country, living with groups of vagrants, and settled in places such as Provincetown, Massachusetts; British Columbia; San Francisco; Pennsylvania; Jamaica; and Italy. In 1969, Mueller first met film director John Waters at the premiere of his film Mondo Trasho. Mueller subsequently starred in Waters’ films, including a major role as “Cookie the Spy” in Pink Flamingos. After her underground film status had faded, she moved to New York and put down stakes as a writer, journalist, and columnist. In his book Shock Value, John Waters credits Mueller with the title for his 1974 film Female Trouble. When she was hospitalized for pelvic inflammatory disease in Provincetown, Waters and Mink Stole visited Mueller. “What happened, Cook?” Waters asked. “Just a little female trouble, hon,” she replied. From 1976 up until her death, she remained a close friend, artistic collaborator, and photographic subject of Nan Goldin. Goldin created and widely exhibited The Cookie Portfolio 1976–1989, a series of fifteen portraits, after Mueller’s death. One photograph, “Cookie and Vittorio’s Wedding” (1986), documents Mueller’s wedding to Vittorio Scarpati, an Italian artist and jewelry designer from Naples who died of AIDS just seven weeks before Mueller.

Cookie Mueller wrote the health column “Ask Dr. Mueller” for the East Village Eye and later served as art critic for Details. Mueller’s books, Ask Doctor Mueller (1996), a collection of her writings; Walking Through Clear Water in a Pool Painted Black (1990), a memoir; and Garden of Ashes (Hanuman Books, 1990) are cult classics. Other works include the novella Fan Mail, Frank Letters, and Crank Calls (Hanuman Books, 1988) and several collections of short prose. Cookie Mueller died from AIDS-related causes on November 10, 1989 in New York City, aged 40. Her ashes are interred in multiple locations: on the beach near Provincetown; in the flowerbed of the Church of St. Luke in the fields in Greenwich Village; alongside those of Vittorio and her dog Beauty in the Scarpati family crypt in Sorrento, Italy; under the statue of Christ the Redeemer atop Corcovado in Rio de Janeiro; in the South Bronx; and in the holy waters of the Ganges River. She was survived by her son, Max Wolfe Mueller, who appeared in Pink Flamingos.