Casale was originally trained as a medical radiation technologist, but was recruited by his brother Gerald Casale to join his band. After a few line-up changes, Bob Casale would be part of the most popular five-piece incarnation, which included the Casale brothers: Jerry and Bob (“Bob 2”), and the Mothersbaugh brothers: Mark and Bob (“Bob 1”), as well as drummer Alan Myers.  In Devo concerts, Bob Casale played lead/rhythm guitar and keyboards while working with MIDI sampling. He also sang backup vocals, both on albums and at live shows.  Starting in 1984, Bob was the sound engineer for all of Devo’s albums, including Shout, Total Devo, Smooth Noodle Maps and Something for Everybody.

As Devo’s mainstream popularity waned during the mid-1980s and its various members began working on side projects. Casale transitioned to music engineering and production. In the late summer of 1986, he engineered the first solo album for Police guitarist, Andy Summers, recorded at Devo Studios in California. XYZ, featuring songs written and sung by Summers, was then released in 1987. Bob later became a part of the musical production group Mutato Muzika with other members of Devo.

As music engineering and production opportunities expanded for Bob Casale and bandmate Mark Mothersbaugh, Bob began working for television and movies, including Four Rooms, Happy Gilmore, Rushmore, The Royal Tenenbaums and Rugrats Go Wild.  Casale died of heart failure in Los Angeles, California on February 17, 2014.He is survived by his brother Gerald, wife Lisa and two children, Alex and Samantha.