Ilan Ramon was a Colonel (Aluf Mishne) and a fighter pilot in the Israeli Air Force, with thousands of hours of flying experience. In 1974, he graduated as a fighter pilot from the Israel Air Force (IAF) Flight School. From 1974–76 he participated in A-4 Basic Training and Operations. 1976–80 was spent in Mirage III-C training and operations. In 1980, as one of the IAF’s establishment team of the first F-16 Squadron in Israel, he attended the F-16 Training Course at Hill Air Force Base, Utah. From 1981–83, he served as the Deputy Squadron Commander B, F-16 Squadron. In 1981 he was the youngest pilot taking part in Operation Opera, Israel’s strike against Iraq’s unfinished Osiraq nuclear reactor. The facility was destroyed, killing ten Iraqi soldiers and one French researcher. After attending the Tel Aviv University, he served as Deputy Squadron Commander A, 119 Squadron, flying the F-4 Phantom (1988–90). During 1990, he attended the Squadron Commanders Course and between 1990 and 1992, commanded 117 Squadron, flying the F-16. From 1992–94, he was Head of the Aircraft Branch in the Operations Requirement Department. In 1994, he was promoted to the rank of Colonel and assigned as Head of the Department of Operational Requirement for Weapon Development and Acquisition. He stayed at this post until 1998. Ilan Ramon accumulated over 3,000 flight hours on the A-4, Mirage III-C, and F-4, and over 1,000 flight hours on the F-16.

In 1997, Ilan Ramon was selected as a Payload Specialist. He was designated to train as prime for a space shuttle mission with a payload that included a multispectral camera for recording desert aerosol (dust). In July 1998, he reported for training at the Johnson Space Center, Houston, Texas, where he trained until 2003. He flew aboard STS-107, logging 15 days, 22 hours and 20 minutes in space. STS-107 Columbia (January 16 – February 1, 2003). The 16-day flight was a dedicated science and research mission. Working 24 hours a day, in two alternating shifts, crew successfully conducted approximately 80 experiments. Although considered a secular Jew, Ramon reportedly sought to follow Jewish observances while in orbit. In an interview he said, “I feel I am representing all Jews and all Israelis.” Ilan Ramon  was the first spaceflight participant to request kosher food. He reportedly sought advice from a Chabad Lubavitch rabbi, Zvi Konikov, about how to observe the Jewish Sabbath in space, as the period between sunrises in orbit is approximately 90 minutes. This was referenced by the words “Jerusalem we have a problem” in Rabbi Konikov’s speech at the Kennedy Space Center Memorial for Columbia on February 7, 2003. The STS-107 mission ended abruptly when Space Shuttle Columbia was destroyed and its crew perished during re-entry, 16 minutes before scheduled landing.

Ilan Ramon, whose mother and grandmother were survivors of Auschwitz, was asked by S. Isaac Mekel, director of development at the American Society for Yad Vashem, to take an item from Yad Vashem aboard STS-107. Ramon carried with him a pencil sketch, “Moon Landscape”, drawn by 16-year-old Petr Ginz, who died in Auschwitz. Ramon also took with him a microfiche copy of the Torah given to him by Israeli president Moshe Katsav and a miniature Torah scroll (from the Holocaust) that was given him by Prof. Yehoyachin Yosef, a Bergen Belsen survivor. Ramon asked the 1939 Club, a Holocaust survivor organization in Los Angeles, for a symbol of the Holocaust to take into outer space with him. A barbed wire mezuzah by the San Francisco artist Aimee Golant was selected. Ramon also took with him a dollar of the Lubavitcher Rebbe, Rabbi Menachem M. Schneerson.[10] Ramon and the rest of the Columbia crew died over East Texas in the Southern United States during entry into Earth’s atmosphere, 16 minutes prior to scheduled landing.  On November 10, 2013, the American Society for Yad Vashem held a special event with the participation of Petr Ginz’s nephew and Ramon’s son Tal, who performed a song he wrote in memory of his father. Ilan Ramon was survived by his wife Rona and their four children, who were in Florida at the time of the accident.