Mady Christians was born on January 19, 1892 to Rudolph Christians, a well-known German actor, and his wife, Bertha. Her family moved to Berlin when she was one year old, and to New York in 1912, where her father became the Irving Place Theatre’s general manager. Five years later she returned to Europe to study under Max Reinhardt. She appeared in a number of European films prior to the early 1930s. In 1929, she starred in the first full sound film made in Germany It’s You I Have Loved. In 1933, she toured the United States in a play called Marching By and was offered a Broadway contract the following year that allowed her, like a number of other German artists, to seek refuge from the Nazi regime in the United States. On Broadway, Christians played Queen Gertrude in Hamlet and Lady Percy in Henry IV, Part I, staged by director Margaret Webster. Webster was part of a small but influential group of lesbian producers, directors, and actors in theater (a group that included Eva Le Gallienne and Cheryl Crawford). Webster and Christians became close friends: according to Webster biographer Milly S. Barranger, it is likely that they also were lovers. Mady Christians also starred in Lillian Hellman’s Watch on the Rhine. She originated the title role in the 1944 play I Remember Mama. Her last movie roles were in All My Sons, based on the play by Arthur Miller, and Letter from an Unknown Woman, both released in 1948.

During World War II, Mady Christians was involved in political work on behalf of refugees, rights for workers (especially in theater and film), and Russian War relief, political efforts that would bring her to the attention of the Federal Bureau of Investigation (FBI) and other anti-communist institutions and organizations. In addition to her political work, Christians also publicly criticized the House Committee on Un-American Activities in early 1941 and likened the Senate Internal Security Subcommittee’s investigation of propaganda in US film to Nazi harassment of film and radio artists in the 1930s. In 1950, the FBI’s internal security division began investigating Christians, who had been identified as a “concealed communist” by a confidential informant. When Christians’ name appeared in Red Channels, the so-called bible of the broadcast blacklist, her career was effectively over. On October 28, 1951, aged 59, Mady Christians died of a stroke, which some attributed to the stress of being subjected to FBI surveillance and being blacklisted.